Best Hotels on Main Street Greenville SC

We checked thousands of reviews on and to find the best hotels for your stay
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Brandon Fuller

Updated: 07 March 2024 · 3 min

Nestled in the lively heart of South Carolina, Greenville is a vibrant city that blends Southern charm with modern sophistication, offering a perfect backdrop for both leisure and business travelers. At the core of this bustling metropolis is Main Street, the city's thriving artery, dotted with an eclectic mix of shops, restaurants, and cultural landmarks. Choosing a hotel on Main Street not only places you in the epicenter of Greenville's vibrant lifestyle but also ensures that the city's best offerings are just a stone's throw away.

The hotels on Main Street Greenville SC cater to a wide range of preferences and budgets, making it easy for every traveler to find their perfect stay. From luxurious boutiques offering personalized services to cost-effective options that don't compromise on comfort, Main Street's accommodations are designed to enhance your Greenville experience. Each hotel boasts unique features and amenities, from stunning city views to gourmet dining options, ensuring your stay is as enjoyable as it is convenient.

For those eager to immerse themselves in the local culture, staying on Main Street is a gateway to discovery. Here, you are perfectly positioned to explore Greenville's flourishing arts scene, from the Greenville County Museum of Art to spontaneous street performances that capture the city's creative spirit. The proximity to outstanding dining and shopping means that your adventure begins the moment you step out of your hotel. Let's embark on a journey to discover the top hotels on Main Street Greenville SC, where comfort meets convenience, ushering in an unforgettable travel experience.
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Our Top 6

(Sorted by rating & number of reviews)

1. Baymont By Wyndham Greenville
2. Quality Inn & Suites Greenville I-65
3. Hampton Inn - Greenville
4. Days Inn By Wyndham Greenville
5. Best Western Greenville Inn
6. Holiday Inn Express Hotel & Suites Greenville, An Ihg Hotel

Affordable Comfort: Budget-Friendly Hotels near Main Street Greenville SC

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Greenville
Dec 12, 2025 - Dec 13, 2025

Baymont By Wyndham Greenville

6.4

Good

(56 Reviews)

+ 40 photos
For those seeking a blend of value and comfort near Greenville's Main Street, the Baymont by Wyndham Greenville offers an ideal solution. This hotel meets the needs of both leisure and business travelers with its well-appointed rooms, free breakfast, and friendly service. The location ensures guests are never too far from the excitement and elegance of Main Street's offerings, from art galleries to gourmet eateries. The outdoor pool and fitness center allow for relaxation and activity, ensuring a well-rounded visit. The Baymont by Wyndham stands as a testament to comfortable stays without compromising on quality or access to local attractions.
Address: 71 Jameson Ln
Rating: Good 6.4 (56 Reviews)
Rooms: 41
Price: From 65$

Affordable Comfort: Budget-Friendly Hotels near Main Street Greenville SC

Quality Inn & Suites Greenville I-65

6.6

Good

(287 Reviews)

+ 72 photos
The Quality Inn & Suites Greenville I-65 stands as a beacon of affordability and comfort for travelers. This hotel packages essential amenities—such as free Wi-Fi, breakfast, and an outdoor pool—into a budget-friendly stay. Guests are treated to comfortable, clean rooms that serve as a quiet retreat after a day of exploring Greenville's attractions, which are easily accessible from the hotel. The friendly staff and the value-added services, including a business center, make this hotel a prudent choice for both leisure and business travelers looking for practical accommodation options.
Address: 941 Fort Dale Road
Rating: Good 6.6 (287 Reviews)
Rooms: 86
Price: From 82$

Hampton Inn - Greenville

8.2

Good

(80 Reviews)

+ 86 photos
The Hampton Inn - Greenville offers a blend of comfort and convenience, making it a standout option for travelers looking for quality accommodations. Situated with easy access to the vibrant life of Greenville, this hotel ensures a stay that’s both relaxing and invigorating. Guests can enjoy spacious rooms equipped with modern amenities, a complimentary hot breakfast to kick start their day, and an outdoor pool for a refreshing dip. The hotel’s proximity to local attractions and dining options on Greenville’s Main Street area enriches every visitor's experience. The attentive staff and cozy atmosphere make it a perfect retreat after a day of exploring the city’s charms.
Address: 219 Interstate Drive
Rating: Good 8.2 (80 Reviews)
Rooms: 69
Price: From 116$

Days Inn By Wyndham Greenville

6.1

Good

(92 Reviews)

+ 34 photos
The Days Inn by Wyndham Greenville provides an economical stay without compromising on the essentials that make a trip enjoyable. Guests can take advantage of amenities such as free breakfast, Wi-Fi, and parking, all wrapped up in a package that emphasizes value and convenience. The hotel's proximity to local dining, shopping, and Greenville's attractions ensures that guests have a comfortable base to return to after a day of exploration. Whether traveling for business or leisure, the Days Inn offers a no-frills, pleasant accommodation option.
Address: 946 Fort Dale Road
Rating: Good 6.1 (92 Reviews)
Rooms: 39
Price: From 77$

Best Western Greenville Inn

7.7

Good

(281 Reviews)

+ 50 photos
At the Best Western Greenville Inn, guests can expect a welcoming atmosphere that caters to a wide range of travel needs without breaking the bank. This hotel offers comfortable rooms equipped with modern conveniences, a seasonal outdoor pool for relaxation, and a complimentary breakfast to start the day right. Its location allows for easy access to the vibrant life of Greenville, including areas close to Main Street, making it an excellent base for exploring the city. The combination of affordability, comfort, and friendly service makes the Best Western Greenville Inn a smart choice for cost-conscious travelers.
Address: 56 Cahaba Road
Rating: Good 7.7 (281 Reviews)
Rooms: 45
Price: From 135$

Holiday Inn Express Hotel & Suites Greenville, An Ihg Hotel

9.3

Good

(195 Reviews)

+ 82 photos
Nestled in a convenient location, the Holiday Inn Express Hotel & Suites offers a warm, welcoming base for visitors to Greenville. This hotel prides itself on combining modern comfort with exceptional service, ensuring a stay that's both enjoyable and stress-free. Guests can take advantage of the spacious rooms, complimentary breakfast, and fitness center. Its easy access to Greenville's Main Street area places guests in the heart of the city’s cultural and dining experiences. Whether you're in town for business or leisure, this hotel provides a pleasant escape that caters to a wide array of preferences and needs.
Address: 100 Paul Stabler Drive
Rating: Good 9.3 (195 Reviews)
Rooms: 67
Price: From 145$